| Hawks | De'Andre Hunter | F-G | Out for season | Torn right meniscus | De'Andre Hunter to undergo season-ending meniscus surgery. | Jun 9 |
| Hawks | Onyeka Okongwu | F-C | Out indefinitely | Torn right shoulder labrum | Onyeka Okongwu underwent shoulder surgery; expected to miss 6 months. | Jul 22 |
| Celtics | Jaylen Brown | F | Out for season | Left wrist surgery | Jaylen Brown to undergo season-ending wrist surgery. | May 10 |
| Nets | LaMarcus Aldridge | F | Out for season | Irregular heartbeat | LaMarcus Aldridge announces retirement from NBA. | Apr 15 |
| Nets | Edmond Sumner | G | Out indefinitely | Torn left Achilles | Edmond Sumner diagnosed with torn Achilles. | Sep 9 |
| Bulls | Coby White | G | Out indefinitely | Left shoulder surgery | Coby White underwent shoulder surgery; out at least 4 months. | Jun 10 |
| Cavaliers | Dylan Windler | G-F | Out for season | Left knee surgery | Windler is out for season with knee | Apr 21 |
| Nuggets | Jamal Murray | G | Out indefinitely | Torn left ACL | Jamal Murray diagnosed with torn ACL. | Apr 13 |
| Warriors | Klay Thompson | G | Out indefinitely | Torn right Achilles | Klay Thompson diagnosed with torn Achilles. | Feb 24 |
| Warriors | James Wiseman | C | Out indefinitely | Torn right meniscus | James Wiseman to undergo knee surgery. | Apr 14 |
| Rockets | David Nwaba | G-F | Out indefinitely | Right wrist surgery | David Nwaba to undergo wrist surgery. | Mar 20 |
| Pacers | T.J. Warren | F | Out indefinitely | Left foot stress fracture | TJ Warren remains out indefinitely. | Sep 8 |
| Clippers | Serge Ibaka | F | Out for season | Back surgery | Serge Ibaka underwent season-ending back surgery. | Jun 11 |
| Clippers | Kawhi Leonard | F | Out indefinitely | Right knee surgery | Kawhi Leonard underwent surgery to repair partial ACL tear. | Jul 14 |
| Grizzlies | Jarrett Culver | G-F | Out for season | Right ankle surgery | Jarrett Culver to undergo season-ending ankle surgery. | Apr 29 |
| Heat | Victor Oladipo | G | Out indefinitely | Right quad tendon surgery | Victor Oladipo to undergo season-ending quad surgery. | May 12 |
| Bucks | Thanasis Antetokounmpo | F | Out | Health and safety protocols | Antetokounmpo is out with covid protocols | Jul 17 |
| Bucks | Donte DiVincenzo | G | Out indefinitely | Torn left ankle ligament | Donte DiVincenzo to miss rest of playoffs. | May 28 |
| Timberwolves | Patrick Beverley | G | Suspended | One-game suspension | Patrick Beverley suspended 1 game. | Jul 7 |
| Timberwolves | Taurean Prince | F | Out indefinitely | Left ankle surgery | Taurean Prince expected to undergo season-ending ankle surgery. | Jul 1 |
| Pelicans | Josh Hart | G | Out indefinitely | Right thumb surgery | Josh Hart underwent thumb surgery; out at least 3 weeks. | Apr 6 |
| Pelicans | Zion Williamson | F | Out indefinitely | Fractured left ring finger | Zion Williamson out indefinitely with fractured finger. | May 7 |
| Knicks | Mitchell Robinson | C-F | Out indefinitely | Right foot surgery | Mitchell Robinson underwent successful foot surgery. | Mar 29 |
| Magic | Michael Carter-Williams | G | Out indefinitely | Left ankle surgery | Michael Carter-Williams underwent ankle surgery; to miss beginning of 2021-22 season. | Sep 8 |
| Magic | Markelle Fultz | G | Out for season | Torn left ACL | Markelle Fultz to miss rest of season with torn ACL. | Feb 24 |
| Magic | Jonathan Isaac | F | Out for season | Torn left ACL | Isaac is out for season with knee | Feb 24 |
| Suns | Dario Saric | F-C | Out indefinitely | Torn right ACL | Dario Saric diagnosed with torn ACL. | Jul 7 |
| Trail Blazers | Larry Nance Jr. | F-C | Out indefinitely | Fractured right thumb | Larry Nance Jr. diagnosed with fractured thumb. | Apr 26 |
| Trail Blazers | Marquese Chriss | F | Out for season | Broken right leg | Marquese Chriss to miss rest of season with broken fibula. | Feb 24 |
| Spurs | Zach Collins | F-C | Out indefinitely | Fractured left foot | Zach Collins re-fractures foot. | Jun 29 |
| Raptors | Pascal Siakam | F | Out indefinitely | Torn left labrum | Pascal Siakam underwent shoulder surgery; expected to miss around 5 months. | Jun 11 |
| Wizards | Spencer Dinwiddie | G | Out indefinitely | Torn right ACL | Spencer Dinwiddie diagnosed with partially torn ACL. | Feb 24 |
| Wizards | Thomas Bryant | C-F | Out for season | Torn left ACL | Thomas Bryant diagnosed with torn ACL. | Jan 10 |
| Wizards | Deni Avdija | F | Out for season | Fractured right ankle | Deni Avdija to miss rest of season with fractured ankle. | Apr 22 |
